17th Iranian Chemistry Congress , 2014-09-01

Title : ( A convenient Fe(HSO 4 ) 3 -catalyzed method for the conversion of aldehyde to nitrile )

Authors: hassan taheri , Ali Shiri , Hossein Eshghi ,

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Background: Nitriles are industrially important intermediates for the production of agrochemicals, pharmaceuticals, polymers, dyes, and pigments.[1] In addition, they serve as potential synthon for the functional group transformation and heterocyclic synthesis.[2] The use of various catalytic systems has been established for the oxidative transformation of nitrile from the substrates like alcohols, amines and amides.[3] The direct oxidative rearrangement of alkene,[4] and methyl arenes,[5] into nitriles have also been known. Methods: Ferric hydrogen sulfate was prepared and conducted to find the advantage of it in the conversion of aldehydic compounds into nitrile-containing ones. We have chosen 4-chlorobenzaldehyde as our model compound for the desired transformation. Therefore, the reaction conditions were initially optimized using the mole-ratio of the catalyst, reaction time, temperature of the reaction, the kind of solvent for the model reaction. After the optimization, the treatment of various derivatives of aldehydic-containing compounds with hydroxylamine hydrochloride in the presence of catalytic amount of Fe(HSO 4 ) as catalyst in refluxing DMF gave the corresponding nitrile compounds in good to excellent yields. 3

Keywords

, Ferric hydrogen sulfate, aldehyde, nitrile, functional group
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@inproceedings{paperid:1042909,
author = {Taheri, Hassan and Shiri, Ali and Eshghi, Hossein},
title = {A convenient Fe(HSO 4 ) 3 -catalyzed method for the conversion of aldehyde to nitrile},
booktitle = {17th Iranian Chemistry Congress},
year = {2014},
location = {رفسنجان, IRAN},
keywords = {Ferric hydrogen sulfate; aldehyde; nitrile; functional group transformation},
}

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%0 Conference Proceedings
%T A convenient Fe(HSO 4 ) 3 -catalyzed method for the conversion of aldehyde to nitrile
%A Taheri, Hassan
%A Shiri, Ali
%A Eshghi, Hossein
%J 17th Iranian Chemistry Congress
%D 2014

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