22nd Iranian Seminar of Organic Chemistry , 2014-08-19

Title : ( Synthesis of new heterocyclic system: 2-substituted-4-methyl-5,11dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine )

Authors: marzieh akbarzadeh , Mehdi Bakavoli , Hossein Eshghi , Atena Jabbari alamdasht , majid mokaber , mehdi mirzaei ,

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The development of heterocyclic scaffolds is a fast emerging subject in medicinal chemistry. Among these, benzo-fused sulfurated seven-membered lactams are endowed with a large spectrum of biological activities with a wide range of interesting, physiological activities. For example, Benzothiazepines play a unique role in drug discovery programs, as they display a wide spectrum of biological activities such as antibacterial [1], antifeedant [2], analgesic [3] and anticonvulsant [4] In this study, 5-hydroxymethyl-6-methyl-1,2,3,4-tetrahydro-2,4-pyrimidinedione(1) was prepared according to the previous procedure and treated with POCl to obtainquantitatively2,4-dichloro-5-chloromethyl-6-methylpyrimidine(2) as precursors. The reaction of compound (2) with 2-Aminothiophenol and treatment with appropriate secondary aminesattained the corresponding heterocyclic system derivatives of 2-substituted-4-methyl5,11-dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine in good yields. . 3

Keywords

, “Benzothiazepine”, “ pyrimidine”, “pyrimidothiazepine”, “antibacterial
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@inproceedings{paperid:1043068,
author = {Akbarzadeh, Marzieh and Bakavoli, Mehdi and Eshghi, Hossein and Jabbari Alamdasht, Atena and Mokaber, Majid and Mirzaei, Mehdi},
title = {Synthesis of new heterocyclic system: 2-substituted-4-methyl-5,11dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine},
booktitle = {22nd Iranian Seminar of Organic Chemistry},
year = {2014},
location = {تبریز, IRAN},
keywords = {“Benzothiazepine”; “ pyrimidine”; “pyrimidothiazepine”; “antibacterial activity},
}

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%0 Conference Proceedings
%T Synthesis of new heterocyclic system: 2-substituted-4-methyl-5,11dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine
%A Akbarzadeh, Marzieh
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Jabbari Alamdasht, Atena
%A Mokaber, Majid
%A Mirzaei, Mehdi
%J 22nd Iranian Seminar of Organic Chemistry
%D 2014

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