Pyrimidine derivatives have recently found wide applications as drugs. These compounds have been synthesized and evaluated as anti-HIV [1], anticancer [2] anti-inflammatory [3] and RET Kinase inhibitors [4]. Moreover, these derivatives can be used as precursors in the synthesis of fused ring compounds and novel heterocycle systems. Four novel 6,8-dimethyl-2-(methylthio)-4-(amino substituted)pyrazolo[1,5-α:3,4-dˊ]dipyrimidine were prepared via a multistep synthetic sequence beginning from 4-hydroxy-2,6-bis(methylthio)pyrimidine-5-carbonitrile. References [1] - Wang, Y.P.; Chen, F.E.; Clercq, E.D.; Balzarini J.; Pannecouque, C. Eur. J. Med. Chem. 2009, 44, 1016-1023. [2]- Huang, Y.Y.; Wang, L.Y.; Chang, C.H.; KuoKaneko, K.; Takayama, H.; Kimura, M.; Juang, S.H.; Wong, F.F. Tetrahedron, 2012, 68, 9658-9664. [3]- El-Gazzar, A.B.A.; El-Enany M.M.; Mahmoud, M.N. Bioorg. Med. Chem. 2008, 16, 3261-327. [4]- Diner, P.; Alao, J.P.; Söderlund, J.; Sunnerhagen P.; Grøtli, M. J. Med. Chem. 2012, 55, 4872-4876.

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