The 22nd Iranian Seminar of Organic Chemistry , 2014-08-19

Title : ( Synthesis of new heterocyclic compounds based on Pyrazolo[3,4-d]pyrimidine derivatives )

Authors: manijeh mohadeszadeh , satar saberi , Hossein Eshghi ,

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Pyrazole and fused heterocyclic pyrazole derivatives constute an interesting class of heterocycles due to their synthetic versatility and effective biological activities [1-2]. Pyrazolo[3,4-d]pyrimidinederivatives have been found to possess antitumor and antileukemia activity [3]. Multistep synthesis from ‘ethyl 5-amino-4-cyano-1H-pyrazole-1-carboxylate’ with some organic reagents produces ‘1,1'-carbonylbis(6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one)’ in which R1= H,CH3,SCH3 and R2= H,CH3,SCH3,Ph,CH2CH3. References 1. El-Emary, T. I. Synthesis and Biological Activity of Some New Pyrazolo[3,4-b]pyrazines. J.Chin. Chem. Soc. 2006, 53, 391-401. 2. Mansour, A. K.; Eid, M. M.; Khalil, N. S. A. M. Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents. Molecules 2003, 8, 744-755. 3. Anderson, J. D.; Cottam, H. B.; Larson, S. B.; Nord, L. D.; Revankar, G. R.; Robins, R. K. Synthesis of Certain Pyrazolo[3,4-d]pyrimidin-3-one Nucleosides. J. Heterocycl. Chem. 1990, 27,439-453. 4. Bhat, G. A.; Montero, J. L.; Panzica, R. P.; Wotring, L. L.; Townsend, L. B. Pyrazolopyrimidine nucleosides. 12 Synthesis and biological activity of certain pyrazolo[3,4-d]pyrimidine nucleosides related to adenosine. J. Med. Chem. 1981, 24, 1165-1172.

Keywords

, multistep synthesis, pyrazolo[3, 4-d] pyrimidine,
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@inproceedings{paperid:1043439,
author = {Mohadeszadeh, Manijeh and Saberi, Satar and Eshghi, Hossein},
title = {Synthesis of new heterocyclic compounds based on Pyrazolo[3,4-d]pyrimidine derivatives},
booktitle = {The 22nd Iranian Seminar of Organic Chemistry},
year = {2014},
location = {تبریز, IRAN},
keywords = {multistep synthesis; pyrazolo[3;4-d] pyrimidine; heterocyclization;},
}

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%0 Conference Proceedings
%T Synthesis of new heterocyclic compounds based on Pyrazolo[3,4-d]pyrimidine derivatives
%A Mohadeszadeh, Manijeh
%A Saberi, Satar
%A Eshghi, Hossein
%J The 22nd Iranian Seminar of Organic Chemistry
%D 2014

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