Title : ( LaCl3.7H2O: an efficient Lewis acid catalyst for synthesis N-(benzothiazole-2-yl)- O,O-dimethyl-α-aminophosphonates )
Authors: mehdi mirzaei , Hossein Eshghi , Maede Hasanpour Mansour , majid mokaber , Atena Jabbari alamdasht ,
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Abstract
A three-component synthesis of α- aminophosphonate is described from a reaction between aldehydes, 2-aminobenzothiazole, and trimethyl phosphite in the presence of LaCl3.7H2O as a catalyst under solvent-free conditions for the generation of the particular α-aminophosphonates. that are a biologically important compound as peptidomimetics, haptens design in antibody generation [1], and also in enzyme inhibitory activity [2]. In addition, α- aminophosphonate derivatives have broad applications such as herbicids, insecticides, fungicides, antibiotics, and pharmacological agents [3]. This method offers advantages such as short reaction times, good yields, solvent-free conditions, and easy workup with the green aspects by avoiding toxic catalysts and solvents. . Reference 1- Hirschmann, R.; Smith, A. B.; Taylor, C. M.; Benkovic, P. A.; Taylor, S. D.; Yager, K. M.;- Sprengler, P. A.; Venkovic, S. J. Science 1994, 265, 234. 2- Allen, M. C.; Fuhrer, W.; Tuck, B.; Wade, R.; Wood, J. M. J Med Chem 1989, 32, 1652. 3- Foss, F. W.; Snyder, A. H.; Davis, M. D.; Rouse, M.; Okusa, M. D.; Lynch, K. R.; Macdonald, T. L. Bioorg Med Chem 2007, 15, 663.
Keywords
, α- aminophosphonate”, “three-component synthesis”, “2-aminobenzothiazole”.
@inproceedings{paperid:1043440,
author = {Mirzaei, Mehdi and Eshghi, Hossein and Hasanpour Mansour, Maede and Mokaber, Majid and Jabbari Alamdasht, Atena},
title = {LaCl3.7H2O: an efficient Lewis acid catalyst for synthesis N-(benzothiazole-2-yl)- O,O-dimethyl-α-aminophosphonates},
booktitle = {The 22nd Iranian Seminar of Organic Chemistry},
year = {2014},
location = {تبریز, IRAN},
keywords = {α- aminophosphonate”; “three-component synthesis”; “2-aminobenzothiazole”.},
}
%0 Conference Proceedings
%T LaCl3.7H2O: an efficient Lewis acid catalyst for synthesis N-(benzothiazole-2-yl)- O,O-dimethyl-α-aminophosphonates
%A Mirzaei, Mehdi
%A Eshghi, Hossein
%A Hasanpour Mansour, Maede
%A Mokaber, Majid
%A Jabbari Alamdasht, Atena
%J The 22nd Iranian Seminar of Organic Chemistry
%D 2014
