Medicinal herbs have many potential clinical and therapeutic applications in the modern medical setting, as numerous studies have revealed that they contain bioactive components, and have resulted in a better understanding of their physiological, therapeutic and clinical actions. Chevil with the scientific name of Ferulago angulata which belongs to the Apiaceace family is a valuable and endemic plant of west of Iran. This plant grows in mountainous areas of Iran, such as provinces of Khuzestan and Chaharmahal and Bakhtiari. In this study the antimicrobial effect of aqueous and ethanolic extracts of Ferulago angulata were investigated using pour plate and disk agar diffusion methods. In pour plate method, Escherichia coli ATTC 25992 just inhibited by ethanolic extract. In disk agar diffusion method three concentrations (40, 60 and 80 mg/ml) of ethanolic extract and two concentrations (60 and 80 mg/ml) of aqueous extract, had inhibitory effect against Escherichia coli ATTC 25992. Minimum Inhibitory Concentration (MIC( and Maximum Inhibitory Concentration also studied using the dilution method. MIC of aqueous and ethanolic extracts of Ferulago angulata for Escherichia coli was 64 and 32 mg/ml and MBC of aqueous and ethanolic extracts was 128 and 64 mg/ml, respectively. The results showed that the ethanolic extract of Ferulago angulata had greater inhibitory effects on the strain studied compared to aqueous extracts "in vitro"

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