Introduction: In recent decades Cardiovascular disease (CVD) is the important leading cause of death in the world. One of its most insidious forms is coronary heart disease (CHD). There are a number of factors that may contribute to incidence of CHD and physical and psychological side effects of it. But previous research indicates that Type D personality, emotional intelligence, stress, coping styles and Quality of life may be interrelated with CHD patients' Psychopathology. The present survey, studies the prevalence of Psychopathology and the role of psychological factors on it in CHD patients' at imam Reza hospital in Mashhad. Materials & Methods: Through convenience sampling method, 180 CHD patients based on G.Power software were selected and filled in SCl-25, Type D personality, Coping Style Questionnaire, The Perceived Stress Scale, the Emotional Intelligence Scale and Whoqol. Prevalence of psychopathology and conceptualized model of psychopathology were evaluated through path analysis by lisrel software. Results: In the 1 and 2 levels upper average, interpersonal hostility and paranoid believes and Emotional Intelligence was significantly related to perceived stress, coping styles and quality of life. Respectively high and low prevalent psychopathology in coronary heart disease patients. Also the conceptual casual model showed direct and indirect effects of psychopathology in CHD patients. Quality of life, Type D personality and emotional intelligence directly and with mediating role of stress and coping styles could affect significantly of psychopathology of patients. Conclusion: Educating the appropriate personality characters, stress management, positive coping style and EQ could lead to decrease of psychopathology in CHD patients and in result reduce somatic and psychic side effects of it and promoting improvement of patients. Then attention to mental health factors in these patients could prominent help to heart specialist in treatment of heart disease patients.

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