Introduction and Objective: Urinary tract infection (UTI) is the second most common cause of infection in human. Escherichia coli is the most common causes of urinary tract infection, in both gender, so that nearly half of all women at least experience UTI once in their lifetime. Increased risk of UTI in infants, pregnant women, the elderly, and patients with spinal cord injuries following the use of a urinary catheter, diabetes, multiple sclerosis and patients with immune deficiency is reported more. As the E.coli is the most common cause of urinary tract and nosocomial infections, the present study was designed to determine the antimicrobial susceptibility of E.coli in the urine culture of patients admitted to several Hospitals in Rasht. Materials and methods: In this descriptive case– series study, non- randomized purposive sampling was recruited for 195 urine positive sample. Antibiotic resistance profiles (Kirby- Bauer method) were performed according to CLSI guideline against 19 different antibiotics. Combined disk method was used to detect ESBLs producers E.coli. All the data analyzed in SPSS version 19. Results: E.coli strains from 76.93% women and 23.07% men were isolated. The majority of strains isolated from children less than 10 years old. The most antibiotic resistance rates between Penicillins were belonging to Oxacillin, Ampicillin and Amoxicillin (100%, 85.64% and 83.58% respectively). Among cephalosporins, Cephalotin and Cefixime were with highest resistance rate (63.56% and 50.25% respectively) and Cefoxitin had the least resistance rate (11.79%). Among quinolones, the most resistance and susceptibility were belonging to Nalidixic acid (85.12%) and to Ofloxacin (55.9%) respectively. Also, resistance to Nitrofurantoin, Tetracycline and Co-trimoxazol was 8.71%, 75.9% and 63.07% respectively. All strains were susceptible to Imipenem. Gentamycin and Cefoxitin had the least resistance rate after Imipenem (8.2% and 11.79% respectively). Among 195 strains, 39.48% isolates were ESBL producers. Conclusion: In this study the highest susceptibility was observed for Imipenem. Also in clinical practice, it is the first antibiotic prescribed to treat urinary tract infection. The highest resistance belongs to Oxacillin which explains why this drug is not recommended to treat urinary tract infections.

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