Conducting polymers (electroactive conjugated polymers, ECPs) have emerged as one of the most promising transducers for chemical sensors. This is related to the unique electrical, electrochemical and optical properties of conjugated polymers that can be used to convert chemical information into electrical or optical signals in the solid state [1]. In the present research, a conducting polypyrrole (ppy) matrix doped with the sulfated β-cyclodextrins (sβ-CD) was electrosynthesized on a pencil graphite electrodeand used as a potentiometric sensor for the detection of phenobarbital. The sβ-CD was immobilized within the ppy backbone during the growth of the polymer at the surface of pencil graphite electrode by means of cyclic voltammetry. The effect of polymerization condition and on the characteristics of potential response of the sensor was investigated. The concentration of pyrrole and sβ-CD, the electrode type, the number of voltammetric cycles and pH were optimized. Under the optimized conditions, the proposed sensor works satisfactory in the concentration range of 10-3 to 10-1 mol L-1 of phenobarbital with a sub-Nernstian slope (~ 40 mV decade-1 activity) and a fast response time of 5 s. The developed potentiometric sensor has been applied for the potentiometric determination of phenobarbital in wastewater and pharmaceutical formulation samples

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