One of the most basic methods for coping with diseases and relieve pain have been the usage of medicinal plants. Propose of this study is the investigation of analgesic effects of Salvia multicaulis extract in formalin test. In this experimental study, male Wistar rats in 6 group (n=7) include control, Sham with intraperitoneal (i.p.) injection of vehicle and four experimental group that received the i.p. doses of 50, 100, 200 and 400 mg/kg‌ of extract respectively, formalin test were used for evaluation of chemical pain. Evaluation of the pain induced by formalin in experimental groups showed that extract in all doses showed anti-nociceptive effects in both acute phase (p<0.05) and inflammatory phase (p<0.05) of Formalin test in does dependent manner. Flavonoids are inhibitors of nitric oxide synthases. Because of the flavonoids presence in the plant hydro-alcoholic extract, perhaps it could be suggested that significant analgesic effects can be due to inhibition of nitric oxide synthesis enzymes; this in turn blocks the NO production, the mediator which increases after formalin injection. Since the NO is argued to be the mediator of hyperalgesia, thus the decrease of NO production can be considered for plant analgesic activity.

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