Inflammation is one of the physiologic reactions to microbial, chemical or physical stimulus which leads to swelling, redness, warmth and itching in affected area. Our previous study was shown an anti-inflammatory effect of Ferula szowitsiana up to dose of 200mg/kg intrapritonealy (i.p.). In this study the anti-inflammatory effect of the i.p. doses of 200 and 400mg/kg were compared. Then the equevalet concentration for i.p. dose of 400mg/kg is used at the intrathecal administration (i.t) to have a comparison between the anti-inflammatory effects of the extracts at the systemic and central administrations. Hydroalcoholic extract of Ferula szowitsiana was solved in saline, tween80 and ethanol (8/1/1 respectively). Male wistar rats (200-250gr) were placed in 6 groups (n=7): control, i.p. solvent, i.t. solvent, i.p. 200mg/kg, i.p. 400mg/kg and i.t. equivalent of 400mg/kg Inflammation was tested by formalin induced paw edema and measured using plethysmometer method. Antiinflammatory effect of 400mg/kg extract dose was higher than the dose of 200mg/kg at the i.p. administration but non significant. Also there was no difference between Anti-inflammatory effects of extract in dose of 400mg/kg, i.p. and its i.t. equivalent concentration.‌Comparison between systemic and central administration suggest that most anti-inflammatory effect of extract is because of its influence on CNS. May be this effect is produced by limonene, α pinene, β pinene trough the adenosine and opioidergic system which needs more investigations.

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