In kindling model of seizure, frequently electrical or chemical stimuli Increased neuronal excitability. Regarding high incidence of epilepsy in human society and with respect to insufficient therapies, in this study anti-convulsing effect of an extract of traditionally medicinal Iranian plant, Ferula szowitsiana was experimentally examined. Hydroalcoholic extract of Ferula szowitsiana was prepared and dissolved in saline, tween 80 and ethanol (8/1/1 respectively) as vehicle. Male wistar rats (200-250gr) were divided 2 groups (n=10): control (intraperitoneal injetion (i.p.) of PTZ) and experimental group extract injection (400 mg/kg, i.p.). For kindling induction, 32 mg/kg of PTZ were used (i.p.) in 12 constitutive days with 24 hours intervals until full kindling. The convulsive states (latent periods and severity) were recorded 30 minutes after daily PTZ administration. Results showed that Ferula szowitsiana extract could postpone kindling induction at least for 2 days (P<0.05) and reduce the severity of seizure at least for 58% at the first day of significant seizure induction in the groups (P<0.01). Ferula szowitsiana extract, probably because of substances such as limonene, myrecene, alpha pinene and etc, shows anti-convulsive effect in kindling model of exprimental seizure.The plant (extract) ingredients may acts via inhibitory and excitatory mechanisms of convulsions. More research need to find the exact mechanism of its action.

کلمات کلیدی