Journal of Heterocyclic Chemistry, ( ISI ), Volume (53), No (1), Year (2016-1) , Pages (135-143)

Title : ( Synthesis, Characterization, and Docking Evaluations of New Derivatives of Pyrimido[4,5-c]pyridazine as Potential Human AKT1 Inhibitors )

Authors: ayla hazrathoseyni , Seyed Mohammad Seyedi , Hossein Eshghi , Ali Shiri , mohammad saadatmandzadeh , Ali Reza Berenji ,

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A number of new derivatives of pyrimido[4,5-c]pyridazine have been synthesized from the treatment of 6-acetyl-3-amino-2,5-diphenyl-2,5-dihydropyridazine-4-carbonitrile (1) as precursor with various reactants obtained quantitatively the desired products (2), (5), (7) and (9a-e). The structures of all the synthesized products have been elucidated thoroughly. The potential AKT1 inhibitory activities of these new synthesized compounds have also been studied by docking calculations which have been performed in Gold 5.2 software using Genetic algorithm.

Keywords

, Pyrimido[4, 5-c]pyridazine, Heterocyclization, Inhibitory activity, Docking, Computational
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@article{paperid:1047252,
author = {Hazrathoseyni, Ayla and Seyedi, Seyed Mohammad and Eshghi, Hossein and Shiri, Ali and Saadatmandzadeh, Mohammad and Berenji, Ali Reza},
title = {Synthesis, Characterization, and Docking Evaluations of New Derivatives of Pyrimido[4,5-c]pyridazine as Potential Human AKT1 Inhibitors},
journal = {Journal of Heterocyclic Chemistry},
year = {2016},
volume = {53},
number = {1},
month = {January},
issn = {0022-152X},
pages = {135--143},
numpages = {8},
keywords = {Pyrimido[4;5-c]pyridazine; Heterocyclization; Inhibitory activity; Docking; Computational chemistry},
}

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%0 Journal Article
%T Synthesis, Characterization, and Docking Evaluations of New Derivatives of Pyrimido[4,5-c]pyridazine as Potential Human AKT1 Inhibitors
%A Hazrathoseyni, Ayla
%A Seyedi, Seyed Mohammad
%A Eshghi, Hossein
%A Shiri, Ali
%A Saadatmandzadeh, Mohammad
%A Berenji, Ali Reza
%J Journal of Heterocyclic Chemistry
%@ 0022-152X
%D 2016

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