-Enaminones, also known as -ketoenamines, are famous because they can be found in biological systems such as DNA base pairs, proteins, and ligand receptor interactions [1,2].They are also applied as antidepressant, anticonvulsant, antitumor, and psychoactive drugs [3-5]. According to the experimental and theoretical investigations on the structure of these compounds, in some cases NH… O systems are dominant but the functional groups in  and  positions can change the hydrogen bond strength [6-9]. The hydrogen bond strength in 3-amino-1-phenyl-2-buten-1-one (APBO)'s derivatives have been investigated using density functional theory (DFT) calculations and experimental results. It was concluded that the hydrogen bond strength in (APBO)'s derivatives is higher than APBO.

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