Title : ( A rapid metal free synthesis of 5-substituted-1Htetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst )
Authors: Sara Ghodsinia , Batool Akhlaghinia ,
Full TextAbstract
A convenient, rapid and metal free synthesis of 5-substituted-1H-tetrazoles is described by [3 + 2] cycloaddition reaction of nitriles with sodium azide. The reaction was catalyzed by cuttlebone in DMSO at 110 0C. Cycloaddition reaction of nitriles with sodium azide happened in the presence of mesoporous cuttlebone by “electrophilic activation” of nitriles through hydrogen bond formation between the cuttlebone and nitrile. Cuttlebone as a natural low cost heterogeneous catalyst with high porosity, high flexural stiffness, high compressive strength and high thermal stability affords 5-substituted-1Htetrazoles rapidly with high efficiency.
Keywords
, Metal free synthesis, 5-Substituted-1H-tetrazoles, Nitriles, Sodium azide, Cycloaddition reaction, Mesoporous cuttlebone, Heterogeneous catalyst.
@article{paperid:1048186,
author = {Ghodsinia, Sara and Akhlaghinia, Batool},
title = {A rapid metal free synthesis of 5-substituted-1Htetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst},
journal = {RSC Advances},
year = {2015},
volume = {5},
number = {5},
month = {May},
issn = {2046-2069},
pages = {49849--49860},
numpages = {11},
keywords = {Metal free synthesis; 5-Substituted-1H-tetrazoles; Nitriles; Sodium azide; Cycloaddition reaction; Mesoporous cuttlebone; Heterogeneous catalyst.},
}
%0 Journal Article
%T A rapid metal free synthesis of 5-substituted-1Htetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst
%A Ghodsinia, Sara
%A Akhlaghinia, Batool
%J RSC Advances
%@ 2046-2069
%D 2015
