Archives of Iranian Medicine, Volume (18), No (6), Year (2015-6) , Pages (376-378)

Title : ( Association of rs12255372 (TCF7L2) and D76N (PDX-1) Polymorphisms with Type 2 Diabetes in a Population Living in Northeast Iran )

Authors: Roya Rafati , Razieh Jalal , Ahmad Asoodeh , Maryam Moghaddam Matin ,

Citation: BibTeX | EndNote

The aim of this study was to investigate whether the rs12255372 (TCF7L2) and D76N (PDX-1) polymorphisms are associated with type 2 diabetes mellitus (T2DM) in Mashhad, northeast Iran. A hundred twenty seven patients with T2DM and 71 non-diabetic controls in Mashhad were genotyped by PCR-RFLP and ARMS-PCR methods. Single nucleotide polymorphisms (SNPs) were confirmed by sequencing in some samples and allelic and genotypic frequencies were then analyzed in each group. The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12–6.49, P = 0.027) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60–7.68, P = 0.002) were significantly associated with an increased risk of T2DM. The rs12255372 SNP of TCF7L2 and D76N of PDX-1 genes may confer susceptibility to T2DM in the population living in Mashhad.

Keywords

, D76N, rs12255372, PDX-1, TCF7L2, Type 2 diabetes
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@article{paperid:1048284,
author = {Rafati, Roya and Jalal, Razieh and Asoodeh, Ahmad and Moghaddam Matin, Maryam},
title = {Association of rs12255372 (TCF7L2) and D76N (PDX-1) Polymorphisms with Type 2 Diabetes in a Population Living in Northeast Iran},
journal = {Archives of Iranian Medicine},
year = {2015},
volume = {18},
number = {6},
month = {June},
issn = {1029-2977},
pages = {376--378},
numpages = {2},
keywords = {D76N; rs12255372; PDX-1; TCF7L2; Type 2 diabetes mellitus},
}

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%0 Journal Article
%T Association of rs12255372 (TCF7L2) and D76N (PDX-1) Polymorphisms with Type 2 Diabetes in a Population Living in Northeast Iran
%A Rafati, Roya
%A Jalal, Razieh
%A Asoodeh, Ahmad
%A Moghaddam Matin, Maryam
%J Archives of Iranian Medicine
%@ 1029-2977
%D 2015

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