Acetaminophen is one of the most popular and widely used anti-inflammatory drugs for the treatment of pain and fever. To date, a variety of methods such as high performance liquid chromatography, spectrofluorimetry, and spectrophotometry have been developed for the determination of acetaminophen [1]. Acetaminophen is an electroactive material which can be oxidized under proper conditions. In the present research, a slice of Digital Versatile Disc (DVD) platform modified with electrodeposited gold nanoparticles (AuNPs) is introduced as a novel voltammetric sensor for determination of acetaminophen. AuNPs were deposited electrochemically on a DVD platform using cyclic voltammetry (CV) by scanning the potential in a solution containing KCl, HCl and HAuCl4 [2]. Also, linear sweep voltammetry (LSV) was applied for voltammetric assay of acetaminophen oxidation at the proposed modified AuNPs@DVD electrode. The catalytic oxidation peak currents obtained from LSV increased linearly with increasing acetaminophen concentration in the range of 3 × 10-5 to 1 × 10-2 M with a limit of detection of 1 × 10-5 M. The reproducibility of the method was obtained as the %RSD which was 6.8%. The AuNPs@DVD electrode shows improved performance regarding sensitivity in comparison to commercial gold electrodes. In addition, they show good stability, easy application, and low cost. The method has been applied for the assay of acetaminophen in several pharmaceutical samples.

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