Title : ( A potential-gated molecularly imprinted smart electrode for nicotinamide analysis )
Authors: Najmeh Karimian , Mohammad Hossein Arbab Zavar , Mahmod CHamsaz , Narjes Ashraf , Anthony P. F. Turner , Ashutosh Tiwari ,
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Abstract
Triggered surface responsiveness paves the way for smart sensor technologies that not only have tunable retention, but also provide sensing through a ‘built-in’ programming of electrode material. In this study, we report a potential-gated electrochemical sensor for determination of nicotinamide (NAM) based on a molecularly imprinted overoxidised polypyrrole electrode. The sensitive layer was prepared by electropolymerisation of pyrrole on a glassy carbon electrode in the presence of NAM as a template molecule, followed by alkali extraction. Electrochemical methods were used to monitor the processes of electropolymerisation, template removal and binding in the presence of a [Fe(CN)6]3/[Fe(CN)6]4 redox couple as an electrochemical probe. Several factors affecting the performance of the MIP-modified electrode were investigated and optimized. The peak current of the ferro/ferricyanide couple decreased linearly with successive addition of NAM in the concentration range 0.9 106 to 9.9 103 M with a detection limit of 1.7 107 M (S/N ¼ 3). The molecularly-imprinted polymer (MIP) electrode had excellent recognition capability for NAM compared to structurally related molecules. Moreover, the reproducibility and repeatability of the NAM-imprinted electrode were all found to be satisfactory. The results from sample analysis confirmed the applicability of the NAM-imprinted electrode to reusable quantitative analysis in commercial pharmaceutical samples.
Keywords
, molecularly imprinted, smart electrode, nicotinamide
@article{paperid:1048392,
author = {Karimian, Najmeh and Arbab Zavar, Mohammad Hossein and CHamsaz, Mahmod and Ashraf, Narjes and Anthony P. F. Turner and Ashutosh Tiwari},
title = {A potential-gated molecularly imprinted smart electrode for nicotinamide analysis},
journal = {RSC Advances},
year = {2015},
volume = {5},
number = {1},
month = {March},
issn = {2046-2069},
pages = {35089--35096},
numpages = {7},
keywords = {molecularly imprinted; smart electrode; nicotinamide},
}
%0 Journal Article
%T A potential-gated molecularly imprinted smart electrode for nicotinamide analysis
%A Karimian, Najmeh
%A Arbab Zavar, Mohammad Hossein
%A CHamsaz, Mahmod
%A Ashraf, Narjes
%A Anthony P. F. Turner
%A Ashutosh Tiwari
%J RSC Advances
%@ 2046-2069
%D 2015
