Quinoline is a well-known structural unit in several natural compounds (cincona alkaloids) and synthetic analogues with interesting biological activities [1]. The biological activity of quinoline derivatives has been found to possess antiasthmatic, antibacterial and antihypertensive properties [2]. The Friedla¨nder reaction is a well-known, simple, and most straightforward protocol for preparing quinolines and related bicyclic compounds.. A mixture of 2-amino acetophenone (1.0 mmol), a-methylene carbonyl compound (1.2 mmol) and catalyst (0.2 g) were added to a pyrex tube fitted with a ground glass joint. These compounds were ground together using a glass rod at100 ◦C. We have developed an acceptable protocol for synthesis of a series of quinoline derivatives were synthesized with Cesuim Iodid via the Friedla¨nder reaction in high to excellent yields. We have developed a green metod for the synthesis of derivatives quinolin with using aromatic 2-aminoaldehyde or ketone and an aldehyde or ketone with an amethylene functionality under acidic condition. short reaction time and solvent free condition are the advantages of this method . References [1] G. Roma, M.D. Braccio, G. Grossi, et al. Eur. J. Med. Chem. 35 (2000) 1021. [2] B. Kalluraya, S. Sreenivasa, Farmaco 53 (1998) 399. [3] P.G. Dormer, K.K. Eng, R.N. Farr, et al. J. Org. Chem. 68 (2003) 467.

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