Title : ( Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex )
Authors: parirokh lavaee , Hossein Eshtiagh Hosseini , Mohammad Reza Housaindokht , Joel T. Mague , Abbas Ali Esmaeili , Khalil Abnous ,
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Abstract
Zinc(II) and copper(II) complexes containing Schiff base, 2- methoxy-6((E)-(phenylimino) methyl) phenol ligand (HL) were synthesized and characterized by elemental analysis, IR, NMR, and single crystal X-ray diffraction technique. The fluorescence properties and quantum yield of zinc complex were studied. Our data showed that Zn complex could bind to DNA grooves with Kb = 104 M−1. Moreover, Zn complex could successfully be used in staining of DNA following agarose gel electrophoresis. MTT assay showed that Zn complex was not cytotoxic in MCF-7 cell line. Here, we introduce a newly synthesized fluorescence probe that can be used for single and double stranded DNA detection in both solution and agarose gels.
Keywords
Copper . Zinc . Schiff base . Interaction . DNA . Fluorescence
@article{paperid:1052648,
author = {Lavaee, Parirokh and Eshtiagh Hosseini, Hossein and Housaindokht, Mohammad Reza and Joel T. Mague and Esmaeili, Abbas Ali and Khalil Abnous},
title = {Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex},
journal = {Journal of Fluorescence},
year = {2016},
volume = {26},
number = {1},
month = {February},
issn = {1053-0509},
pages = {333--344},
numpages = {11},
keywords = {Copper . Zinc . Schiff base . Interaction . DNA . Fluorescence},
}
%0 Journal Article
%T Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex
%A Lavaee, Parirokh
%A Eshtiagh Hosseini, Hossein
%A Housaindokht, Mohammad Reza
%A Joel T. Mague
%A Esmaeili, Abbas Ali
%A Khalil Abnous
%J Journal of Fluorescence
%@ 1053-0509
%D 2016
