Tetrahedron Letters, ( ISI ), Volume (57), No (1), Year (2016-1) , Pages (100-102)

Title : ( Efficient synthesis of novel pyrano[2,3- d ]pyrido[1,2- a ]pyrimidine derivatives via isocyanide-based three-component reactions )

Authors: Abbas Ali Esmaeili , fariba salehan , Azizollah Habibi , Ali Reza Fakhari ,
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Abstract

The synthesis of novel tricyclic fused pyrano[2,3-d]pyrido[1,2-a]pyrimidines containing both biologically active pyridopyrimidine and pyranopyrimidine scaffolds, via the reaction of 2H-pyrido[1,2-a]pyrimidine- 2,4(3H)-dione, isocyanides, and dialkylacetylenedicarboxylates are reported. The products were obtained in good to excellent yields over short reaction times and with a simple work-up procedure.

Keywords

, Multi-component reaction, Pyranopyridopyrimidine, Acetylenic esters, Alkyl isocyanide, One-pot synthesis