Title : ( Synthesis of new derivatives of 10H-benzo[b] pyridazino[3,4-e][1,4]thiazines )
Authors: zahra arghiani , Seyed Mohammad Seyedi , Mehdi Bakavoli , Mohsen Nikpour ,
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Abstract
New 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.
Keywords
, 4-bromo-3, 6-dichloropyridazine; 4-bromo-1, 2-dihydropyridazine-3, 6-dione; 3-bromomaleic anhydride; 10H-benzo[b]pyridazino[3, 4-e][1, 4]thiazines; heterocyclization; 15-lipoxygenase inhibitor.
@article{paperid:1053861,
author = {Arghiani, Zahra and Seyedi, Seyed Mohammad and Bakavoli, Mehdi and Mohsen Nikpour},
title = {Synthesis of new derivatives of 10H-benzo[b] pyridazino[3,4-e][1,4]thiazines},
journal = {Heterocyclic Communications},
year = {2015},
volume = {21},
number = {4},
month = {August},
issn = {0793-0283},
pages = {215--218},
numpages = {3},
keywords = {4-bromo-3;6-dichloropyridazine; 4-bromo-1;2-dihydropyridazine-3;6-dione; 3-bromomaleic anhydride;
10H-benzo[b]pyridazino[3;4-e][1;4]thiazines; heterocyclization; 15-lipoxygenase
inhibitor.},
}
%0 Journal Article
%T Synthesis of new derivatives of 10H-benzo[b] pyridazino[3,4-e][1,4]thiazines
%A Arghiani, Zahra
%A Seyedi, Seyed Mohammad
%A Bakavoli, Mehdi
%A Mohsen Nikpour
%J Heterocyclic Communications
%@ 0793-0283
%D 2015
