Nuclear Instruments and Methods in Physics Research B, Volume (372), No (1), Year (2016-2) , Pages (7-13)

Title : ( Geant4.10 Simulation of Geometric Model for Metaphase Chromosome )

Authors: Laleh Rafat Motavali , Seyyed Hashem Miri Hakimabad , Effat Bakhtiyari ,

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Abstract

In this paper, a geometric model of metaphase chromosome is explained. The model is constructed according to the packing ratio and dimension of the structure from nucleosome up to chromosome. A B-DNA base pair is used to construct 200 base pairs of nucleosomes. Each chromatin fiber loop, which is the unit of repeat, has 49,200 bp. This geometry is entered in Geant4.10 Monte Carlo simulation toolkit and can be extended to the whole metaphase chromosomes and any application in which a DNA geometrical model is needed. The chromosome base pairs, chromosome length, and relative length of chromosomes are calculated. The calculated relative length is compared to the relative length of human chromosomes.

Keywords

, B, DNA; Chromatin fiber loop; Chromosome; Geant4.10; Relative length
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@article{paperid:1054974,
author = {Rafat Motavali, Laleh and Miri Hakimabad, Seyyed Hashem and Effat Bakhtiyari},
title = {Geant4.10 Simulation of Geometric Model for Metaphase Chromosome},
journal = {Nuclear Instruments and Methods in Physics Research B},
year = {2016},
volume = {372},
number = {1},
month = {February},
issn = {0168-583X},
pages = {7--13},
numpages = {6},
keywords = {B-DNA; Chromatin fiber loop; Chromosome; Geant4.10; Relative length},
}

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%0 Journal Article
%T Geant4.10 Simulation of Geometric Model for Metaphase Chromosome
%A Rafat Motavali, Laleh
%A Miri Hakimabad, Seyyed Hashem
%A Effat Bakhtiyari
%J Nuclear Instruments and Methods in Physics Research B
%@ 0168-583X
%D 2016

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