A new design of hyperbranchedpolyglycidol/ graphene oxide nanocomposite reinforced hollow fiber solid/liquid phase microextraction (HBP/GO -HF- SLPME) coupled with high performance liquid chromatography was used for extraction and determination of ibuprofen and naproxen in hair and waste water samples. The graphene oxide first, synthesized from graphite powders by using modified Hummers approach. Graphene oxide was functionalized with hyperbranchedpolyglycidol using direct polycondensation with thionylchloride. The prepared nanocomposite was applied to extract the target analytes indirect immersion sampling mode. After extraction, the analytes were desorbed with methanol, and then detected by high performance liquid chromatography (HPLC).The main factors influencing the extraction of the analytes: pH of the aqueous feed solution, amount of the sorbent, extraction time, aqueous feed volume, agitation speed, and desorption conditions have been examined in detail. Under the optimized conditions, the linearity was observed in the range of 5-30000 ng mL−1 for ibuprofen and 2-10000 ng mL−1 for naproxen with correlation coefficients of 0.9968 and 0.9925, respectively. The limits of detection were 2.95 ng mL−1 for ibuprofen and 1.54 ng mL−1 for naproxen. The relative standard deviations (RSDs) were

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