Introduction: Irisin is a myokine secreted from the muscle in response to exercise. The aim of this study was to investigate the acute and chronic effect of resistance training in sedentary young women. Material and methods: In this study, 21 sedentary young women with range of 20–30 years and BMI 22–25 kg/m2 were selected by convenience sampling. Then, the volunteers were randomly assigned into two groups. The selected training was comprised of 8 weeks, 3 times a week. Blood samples were obtained at baseline, after one session and 48 h at the end of the study. For all statistical comparisons, the level of significance was considered P < 0.05. Result: The results of this study showed that the levels of Irisin, body mass index, and body fat percentage in the low-intensity training group were not significant (P > 0.05). Moreover, no significant changes were shown in body mass index and body fat percentage in high-intensity training (P > 0.05). In contrast, the levels of Irisin in high-intensity training decreased significantly (p = 0.034). In low-intensity RT group and high-intensity RT group, no significant changes were observed in serum Irisin after 1 session. Discussion: These results suggest that one period and one session of resistance training with low intensity and one session of resistance training with high intensity did not change serum Irisin levels significantly; in addition, after one period of weight training with high intensity, serum level of Irisin decreased in young women with a body mass index between 22 and 25 kg per square meter.

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