Title : ( Theoretical Design of a New Generation of the Cyclic Lipopeptide Nanotubes )
Authors: Mohammad Khavani Sariani , Mohammad Izadyar ,
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Abstract
In this article, cyclic peptide (CP) with lipid substitutions were theoretically designed. Dynamical behavior of the cyclic peptide nanotube (CPNT) without lipid substitutions in the solution, water and chloroform, during the 50 ns molecular dynamic (MD) simulations has been investigated. The effect of the lipid substitutions on the CPNT has been studied, too. The substitution increased the stability of the CPNT, significantly, in polar solvents. The behavior of the CPNTs reveals that these structures are good choices for molecule transmission across the lipid membrane and this structure is enough stable to be used as a molecular channel.
Keywords
Cyclic peptide; Nanotube; MD simulation; Lipid Substitutions
@inproceedings{paperid:1055619,
author = {Khavani Sariani, Mohammad and Izadyar, Mohammad},
title = {Theoretical Design of a New Generation of the Cyclic Lipopeptide Nanotubes},
booktitle = {ICN6-6th international conference on nanostructures},
year = {2016},
location = {Kish, IRAN},
keywords = {Cyclic peptide; Nanotube; MD simulation; Lipid Substitutions},
}
%0 Conference Proceedings
%T Theoretical Design of a New Generation of the Cyclic Lipopeptide Nanotubes
%A Khavani Sariani, Mohammad
%A Izadyar, Mohammad
%J ICN6-6th international conference on nanostructures
%D 2016
