Iranian Journal of Basic Medical Sciences, ( ISI ), Volume (19), No (6), Year (2016-6) , Pages (594-600)

Title : ( Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphet- amine withdrawn rats )

Authors: Fatemeh Damghani , Imanollah Bigdeli , Hossein Miladi-Gorji , Atefeh Fadaei ,

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Objective(s): This study evaluated the effect of swimming exercise during spontaneous methamphetamine (METH) withdrawal on the anxiety, depression, obsessive-compulsive disorder (OCD) and voluntary METH consumption in METH-dependent rats. Materials and Methods: Male Wistar rats were repeatedly administered with bi-daily doses of METH (2 mg/kg, subcutaneous) over a period of 14 days. Exercised rats were submitted to swimming sessions (45 min/day, five days per week, for 14 days) during spontaneous METH-withdrawal. Then, all animals were tested for the assessment of anxiety by using the elevated plus-maze (EPM), the grooming behaviors (OCD), and depression using forced swimming test (FST) and voluntary METH consumption using a two-bottle choice (TBC) paradigm for the assessment of craving. Results: The results showed that the swimmer METH-withdrawn rats exhibited an increase in EPM open arm time and entries and a reduction of immobility and grooming behaviors compared with the sedentary METH groups. Also, voluntary METH consumption was less in the swimmer METH-withdrawn rats than the sedentary METH groups throughout 5–8 days. Conclusion: This study showed that regular swimming exercise reduced voluntary METH consumption in animal models of craving by reducing anxiety, OCD, and depression in the METH-withdrawn rats. Thus, physical training may be ameliorating some of the withdrawal behavioral consequences of METH.

Keywords

, Anxiety, ; Craving, ; Depression Methamphetamine- abstinence, ; Obsessive-compulsive disorder, ;
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@article{paperid:1056991,
author = {Fatemeh Damghani and Bigdeli, Imanollah and Hossein Miladi-Gorji and Atefeh Fadaei},
title = {Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphet- amine withdrawn rats},
journal = {Iranian Journal of Basic Medical Sciences},
year = {2016},
volume = {19},
number = {6},
month = {June},
issn = {2008-3866},
pages = {594--600},
numpages = {6},
keywords = {Anxiety;; Craving;; Depression Methamphetamine- abstinence;; Obsessive-compulsive disorder;; Swimming},
}

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%0 Journal Article
%T Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphet- amine withdrawn rats
%A Fatemeh Damghani
%A Bigdeli, Imanollah
%A Hossein Miladi-Gorji
%A Atefeh Fadaei
%J Iranian Journal of Basic Medical Sciences
%@ 2008-3866
%D 2016

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