Iranian Journal of Medical Physics, Volume (12), No (4), Year (2015-12) , Pages (278-283)

Title : ( Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis )

Authors: fatemeh razghandi , Reza Izadi Najafabadi , Ali Mowlavi ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Introduction One of the important applications of nuclear physics in medicine is the use of radioactive elements as radiopharmaceuticals. Metastatic bone disease is the most common form of malignant bone tumors. Samarium-153-ethylene diamine tetramethylene phosphonate (153Sm-EDTMP) as a radiopharmaceutical is used for pain palliation. This radiopharmaceutical usually emits beta particles, which have a high uptake in bone tissues. The purpose of this study was to calculate the radiation dose distribution of 153Sm-EDTMP in bone and other tissues, using MCNPX Monte Carlo code in the particle transport model. Materials and Methods Dose delivery to the bone was simulated by seeking radiopharmaceuticals on the bone surface. The phantom model had a simple cylindrical geometry and included bone, bone marrow, and soft tissue. Results The simulation results showed that a significant amount of radiation dose was delivered to the bone by the use of this radiopharmaceutical. Conclusion The bone acted as a fine protective shield against rays for the bone marrow. Therefore, the trivial absorbed dose by the bone marrow caused less damage to bone-making cells. Also, the high absorbed dose of the bone could destroy cancer cells and relieve the pain in the bone.

Keywords

, Dose Distribution, MCNPX Code,
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1057257,
author = {Razghandi, Fatemeh and Izadi Najafabadi, Reza and Ali Mowlavi},
title = {Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis},
journal = {Iranian Journal of Medical Physics},
year = {2015},
volume = {12},
number = {4},
month = {December},
issn = {1735-160X},
pages = {278--283},
numpages = {5},
keywords = {Dose Distribution; MCNPX Code; 153Sm-EDTMP},
}

[Download]

%0 Journal Article
%T Calculation of the Dose of Samarium-153-Ethylene Diamine Tetramethylene Phosphonate (153Sm-EDTMP) as a Radiopharmaceutical for Pain Relief of bone Metastasis
%A Razghandi, Fatemeh
%A Izadi Najafabadi, Reza
%A Ali Mowlavi
%J Iranian Journal of Medical Physics
%@ 1735-160X
%D 2015

[Download]