Background: Chronic musculoskeletal pain is a worldwide health problem. Anxiety and depression are common among patients suffering from chronic pain. Self-management strategies are used to help patients manage the emotional distress associated with pain. Aim: To evaluate the effects of cognitive pain self-mana gement program (CPSMP) on depression, anxiety, and stress in women with chronic pain. Method: This pilot study with a pretest-posttest design performed on 20 women with chronic pain, who were referred to Imam-Reza and Qaem Clinic Cent ers and Clinical Psychology Center of Ferdowsi University of Mashhad, Iran, during June-O ctober 2014. The participants randomly assigned to experimental and control groups. The in tervention comprised of eight 120-min weekly group sessions. CPSMP employs the principles of cog nitive therapy and self-management program strategies. The control group received regular treatment sessions. At pre-and post-test, the participants completed Depression, Anxiety, and Stress Scale (DASS-21). The data were analyzed using Wilcoxon and Mann-Whitney U tests. Results: The mean ages of the intervention and control groups were 35.2±9 and 32.5±11 years, respectively. After the intervention, Mann-Whitney U test did not reflect a significant difference between the intervention and control groups in term s of depression (P=0.14). Moreover, the results of Mann-Whitney test revealed a significant difference between the groups regarding anxiety (P<0.001) and stress (P=0.04). Implications for Practice: CPSMP can be effective for reducing anxiety and stress in women with chronic pain. Further studies with larger sample sizes and more extended follow-ups are recommended.

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