24th Iranian Seminar of Organic Chemistry , 2016-08-24

Title : ( Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system )

Authors: mansooresadat eigehei , Mehdi Bakavoli , Ali Shiri ,

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Abstract

Pyrimidine and related fused heterocyclic compounds have attracted the attention of numerous researchers due to their important biological. they have been reported asanticancer, antiviral, antitumor, and anti-inflammatory agents [1-2].Moreover, tetrazoles have found utility in pharmaceuticals as lipophilic spacers and carboxylic acid surrogates, in special explosives, photography and information recording systems[3]. Herein, 2,4-dichloro- 5(chloromethyl)-6-methylpyrimidine 1were prepared according to the previous procedure and treated with sodium 1-amino-1H-tetrazole-5-thiolate 2 as abinucleophile in CHCl . to obtain 5-((2,4-dichloro6-methylbenzyl)thio)-1H-tetrazol-1-amine3. Compound 3was further cyclized with K2CO3 in boiling DMF to give the desired novel tricyclic compound4. Treatment of compound 4 with various secondary amines afforded the corresponding products5a-gin yields(Figure 1). All of these compounds were characterized by FT-IR, 1H NMR, 13C NMR and mass spectrometry.

Keywords

, pyrimido[4, 5-e][1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazepine
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@inproceedings{paperid:1057942,
author = {Eigehei, Mansooresadat and Bakavoli, Mehdi and Shiri, Ali},
title = {Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system},
booktitle = {24th Iranian Seminar of Organic Chemistry},
year = {2016},
location = {تبریز, IRAN},
keywords = {pyrimido[4;5-e][1;2;4]triazolo[3;4-b][1;3;4]thiadiazepine},
}

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%0 Conference Proceedings
%T Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system
%A Eigehei, Mansooresadat
%A Bakavoli, Mehdi
%A Shiri, Ali
%J 24th Iranian Seminar of Organic Chemistry
%D 2016

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