Title : ( Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system )
Authors: mansooresadat eigehei , Mehdi Bakavoli , Ali Shiri ,Access to full-text not allowed by authors
Abstract
Pyrimidine and related fused heterocyclic compounds have attracted the attention of numerous researchers due to their important biological. they have been reported asanticancer, antiviral, antitumor, and anti-inflammatory agents [1-2].Moreover, tetrazoles have found utility in pharmaceuticals as lipophilic spacers and carboxylic acid surrogates, in special explosives, photography and information recording systems[3]. Herein, 2,4-dichloro- 5(chloromethyl)-6-methylpyrimidine 1were prepared according to the previous procedure and treated with sodium 1-amino-1H-tetrazole-5-thiolate 2 as abinucleophile in CHCl . to obtain 5-((2,4-dichloro6-methylbenzyl)thio)-1H-tetrazol-1-amine3. Compound 3was further cyclized with K2CO3 in boiling DMF to give the desired novel tricyclic compound4. Treatment of compound 4 with various secondary amines afforded the corresponding products5a-gin yields(Figure 1). All of these compounds were characterized by FT-IR, 1H NMR, 13C NMR and mass spectrometry.
Keywords
, pyrimido[4, 5-e][1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazepine@inproceedings{paperid:1057942,
author = {Eigehei, Mansooresadat and Bakavoli, Mehdi and Shiri, Ali},
title = {Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system},
booktitle = {24th Iranian Seminar of Organic Chemistry},
year = {2016},
location = {تبریز, IRAN},
keywords = {pyrimido[4;5-e][1;2;4]triazolo[3;4-b][1;3;4]thiadiazepine},
}
%0 Conference Proceedings
%T Synthesis of pyrimido[4,5-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine as a Novel heterocyclic system
%A Eigehei, Mansooresadat
%A Bakavoli, Mehdi
%A Shiri, Ali
%J 24th Iranian Seminar of Organic Chemistry
%D 2016