Title : ( Synthesis of novel 3‑ substituted‑ 5H‑ benzo [5,6][1, 4] thiazino [3,2‑e][1,2,4] triazines and their 15‑ lipoxygenase inhibitory activity )
Authors: ali mohammadi , Hossein Eshghi , Mehdi Bakavoli , Farzin Hadizadeh , hassanali moradi ,
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Abstract
A new group of 3-substituted-5H-benzo[5,6] [1,4]thiazino[3,2-e][1,2,4]triazines was designed, synthesized and evaluated as inhibitors of 15-lipoxygenase (15-LO), and the results were compared with those of standard ligand 4-methyl-2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine (4-MMPB). Among the newly designed ligands, compound 9e showed the best IC50 of 15-LO inhibition (IC50 = 38 μM). The docking calculations were performed in MOE software based on the function of force-field scoring, in order to study the interaction of these new compounds and standard ligand with 15-LO. The docking study implied that these ligands have hydrogen bond interaction with the residue of active site of 15-LO.
Keywords
, Fused benzothiazines · 15, Lipoxygenase · Docking · Molecular modelling · Triazines
@article{paperid:1058140,
author = {Mohammadi, Ali and Eshghi, Hossein and Bakavoli, Mehdi and Farzin Hadizadeh and Moradi, Hassanali},
title = {Synthesis of novel 3‑ substituted‑ 5H‑ benzo [5,6][1, 4] thiazino [3,2‑e][1,2,4] triazines and their 15‑ lipoxygenase inhibitory activity},
journal = {Journal of the Iranian Chemical Society},
year = {2016},
volume = {13},
number = {8},
month = {August},
issn = {1735-207X},
pages = {1539--1547},
numpages = {8},
keywords = {Fused benzothiazines · 15-Lipoxygenase · Docking · Molecular modelling · Triazines},
}
%0 Journal Article
%T Synthesis of novel 3‑ substituted‑ 5H‑ benzo [5,6][1, 4] thiazino [3,2‑e][1,2,4] triazines and their 15‑ lipoxygenase inhibitory activity
%A Mohammadi, Ali
%A Eshghi, Hossein
%A Bakavoli, Mehdi
%A Farzin Hadizadeh
%A Moradi, Hassanali
%J Journal of the Iranian Chemical Society
%@ 1735-207X
%D 2016
