Journal of Biological Physics, Volume (42), No (4), Year (2016-9) , Pages (1-16)

Title : ( A new definition and properties of the similarity value between two protein structures )

Authors: Seyed Majid Saberi Fathi ,

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Abstract

Knowledge regarding the 3D structure of a protein provides useful information about the protein’s functional properties. Particularly, structural similarity between proteins can be used as a good predictor of functional similarity. One method that uses the 3D geometrical structure of proteins in order to compare them is the similarity value (SV). In this paper, we introduce a new definition of the SV measure for comparing two proteins. To this end, we consider the mass of the protein’s atoms and concentrate on the number of protein’s atoms to be compared. This defines a new measure, called the weighted similarity value (WSV), adding physical properties to geometrical properties. We also show that our results are in good agreement with the results obtained by TM-SCORE and DALILITE. WSV can be of use in protein classification and in drug discovery.

Keywords

, Weighted similarity value .RMSD .Wigner, D functions
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@article{paperid:1058142,
author = {Saberi Fathi, Seyed Majid},
title = {A new definition and properties of the similarity value between two protein structures},
journal = {Journal of Biological Physics},
year = {2016},
volume = {42},
number = {4},
month = {September},
issn = {0092-0606},
pages = {1--16},
numpages = {15},
keywords = {Weighted similarity value .RMSD .Wigner-D functions},
}

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%0 Journal Article
%T A new definition and properties of the similarity value between two protein structures
%A Saberi Fathi, Seyed Majid
%J Journal of Biological Physics
%@ 0092-0606
%D 2016

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