Title : ( SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol kindled rats )
Authors: Elham kordi jaz , Ali Moghimi , Masoud Fereidoni , Ali Shamsizadeh , Ali Roohbakhsh ,
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Abstract
Convulsive seizures are due to abnormal synchronous and repetitive neuronal discharges in the central nervous system (CNS). Finding new therapeutics to overcome the side effects of the current drug therapies and to increase their effectiveness is ongoing. Orexin-A and orexin-B are brain neuropeptides originated from postero-lateral hypothalamic neurons. Studies show that orexins, through activation of OX1 and OX2 receptors, have excitatory effects in the CNS. Accordingly, the present study was designed to evaluate the effect of OX1 receptor antagonist (SB-334867) on seizure- and anxiety-related behaviors of pentylenetetrazol (PTZ) kindled rats.
Keywords
, Epilepsy, Orexin receptor, Seizure, Anxiety, Kindling, Elevated plus-maze
@article{paperid:1058734,
author = {Kordi Jaz, Elham and Moghimi, Ali and Fereidoni, Masoud and Ali Shamsizadeh and Ali Roohbakhsh},
title = {SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol kindled rats},
journal = {Fundamental & Clinical Pharmacology},
year = {2017},
volume = {2},
number = {2},
month = {April},
issn = {0767-3981},
pages = {201--207},
numpages = {6},
keywords = {Epilepsy; Orexin receptor; Seizure; Anxiety; Kindling; Elevated plus-maze},
}
%0 Journal Article
%T SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol kindled rats
%A Kordi Jaz, Elham
%A Moghimi, Ali
%A Fereidoni, Masoud
%A Ali Shamsizadeh
%A Ali Roohbakhsh
%J Fundamental & Clinical Pharmacology
%@ 0767-3981
%D 2017
