The material world is the arena of interference and restrictions. That's why men always encounter sufferings, deprivations, and frustrations on the one hand, and joy and prosperity on the other hand. The Quran also confirms that human life is accompanied with suffering, (Balad, 4) so bitterness and "stress" is an integral part of human life. We should explore the ways to deal with these despairs and preserve our mental balance in happiness and sadness. In the light of the guidelines of Holy Quran which discusses this matter in multiple verses, it is possible to analyze the right and wrong ways of dealing with the events. Psychology also suggests ways to cope with the difficulties. Having investigated the strategies proposed by Quran and Psychology, the survey is to compare the resulting solutions and findings show that Holy Quran, according to cognitive restructuring based on God- centered worldview, offers better ways to retain human’s balance in despairs and prosperities.

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