Purpose: So far, about the affect of fasting and physical activities on Myostatin and follistatin levels of athletics have not do a particularly studies. The aim of this study was investigated the effects of fasting with regular physical activity training on serum Myostatin and Follistatin levels in elite wrestlers. Methods: Nine elite male wrestlers with an average age of 22.55±1.87 years which were selected by convenience sampling method to take part in this semi-experimental study. The wrestlers participated in selected training for a period of one month consisting of six days a week and include two sessions’ wrestlers training, a special technical review session, a session of aerobic exercise and resistance training. Blood samples were taken once before the first day, on the second week, on the fourth week and two weeks after fasting month. For within-group mean difference repeated measures test were used. The level of significance was set at p<0.05. Results: the result show that weight during Ramadan reduced significantly. However, the levels of serum Myostatin and follistatin also (12 and 10.33 percent respectively) reduced but not significant. Conclusion: According to this result, the levels of serum Myostatin and follistatin also reduced but not significant. Season, intensity, duration, exercise and fitness athletes are the factors that affect on Myostatin and follistatin. Despite the differences in the results of different studies, researchers believe that resistance training lead to reduce the levels of serum Myostatin and follistatin which can reduce muscle atrophy and increase hypertrophy.

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