Title : ( Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction methodcoupled withhigh performance liquid chromatography for determination of mirtazapine and its metabolites in human urineand water samples employingexperimental design )
Authors: mahdi ghorbani , Mahmod CHamsaz , Gholam hossein Ronaghi , Mohsen Aghamohammadhasani , Orkideh Seyedin , Nahid Afshar Lahoori ,
Full TextAbstract
Ultrasonic-assisted magnetic dispersive solid-phase microextraction coupled with high performance liquid chromatography has been developed for extraction and determination of mirtazapine, n-desmethyl mirtazapine and8-Hydroxy mirtazapinein human urineand water samples.Magnetic graphene oxide–polyanilinenanocomposite(MGOPA)as a novel SPME sorbent was synthesized and used for themicroextraction process. The analytical performance of MGOPA was compared with magnetic graphene oxide nanocomposite and indicated that the new sorbent was quite effective for extraction of mirtazapine,n-desmethyl mirtazapine and8-Hydroxy mirtazapine. A two stagesexperimental design approach, Plackett–Burman screening design and Box- Behnken optimization design, was used for screening and optimizing of significant variablesin the microextraction process.The practical applicability of the proposed methodwas assessed by studying the linearity, intra-day and inter-day accuracy, enrichment factor and precision.This method can be satisfactorily applied to the determination of mirtazapine and its metabolites in human urine and environmental water samples.
Keywords
, Graphene oxide nanocomposite; Mirtazapine;Dispersive solid, phase microextraction; Plackett–Burman design; Box, Behnken design; High performance liquid chromotography;
@article{paperid:1060080,
author = {Ghorbani, Mahdi and CHamsaz, Mahmod and Ronaghi, Gholam Hossein and Mohsen Aghamohammadhasani and Orkideh Seyedin and Nahid Afshar Lahoori},
title = {Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction methodcoupled withhigh performance liquid chromatography for determination of mirtazapine and its metabolites in human urineand water samples employingexperimental design},
journal = {Analytical and Bioanalytical Chemistry},
year = {2016},
volume = {408},
number = {27},
month = {August},
issn = {1618-2642},
pages = {7719--7729},
numpages = {10},
keywords = {Graphene oxide nanocomposite; Mirtazapine;Dispersive solid-phase microextraction; Plackett–Burman design; Box- Behnken design; High performance liquid chromotography;},
}
%0 Journal Article
%T Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction methodcoupled withhigh performance liquid chromatography for determination of mirtazapine and its metabolites in human urineand water samples employingexperimental design
%A Ghorbani, Mahdi
%A CHamsaz, Mahmod
%A Ronaghi, Gholam Hossein
%A Mohsen Aghamohammadhasani
%A Orkideh Seyedin
%A Nahid Afshar Lahoori
%J Analytical and Bioanalytical Chemistry
%@ 1618-2642
%D 2016
