Iranian Journal of Public Health, ( ISI ), Volume (44), No (10), Year (2015-10) , Pages (1353-1358)

Title : ( Analysis of Chemokine Receptor Gene Expression in Esophageal Cancer Cells Compared with Breast Cancer with Insights into Metastasis )

Authors: Mohammad Amir Mishan , Asieh Heirani Tabasi , Neda Mokhberian , Malihe Hassanzade , Hamid Kalalian Moghaddam , Ahmad Reza Bahrami , Naghmeh Ahmadiankia ,

Access to full-text not allowed by authors

Citation: BibTeX | EndNote

Background: Chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. In this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines. Methods: In a descriptive study, gene expression profile of CCR1, CCR6, CCR7, CCR9, CXCR1, and CXCR4 in human esophageal cancer cell line (KYSE-30) and human breast cancer cell line (MCF7) were analyzed using real-time PCR and their results were compared accordingly. Results: We demonstrated for the first time the expression of CCR1, CCR6, CCR7, CCR9, CXCR1, and CXCR4 at transcriptional level in human esophageal cancer cell line. The expression of CCR1, CCR7 and CXCR4 were lower in esophageal compared with breast cancer cells, although without significant difference. CCR9 was highly expressed in esophageal cancer cells as compared to the breast cancer cells (P < 0.05). Similarly, the expression of CCR6 and CXCR1 were higher, although without significant difference. Conclusion: Esophageal cancer cells like breast cancer express some key chemokine receptors involved in metastasis. Targeting of proposed receptors in esophageal cancer may be a novel strategy for prevention of cancer metastasis.

Keywords

Esophageal cancer; Breast cancer; Metastasis; Chemokine receptors; Targeted cancer
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1060262,
author = {Mishan, Mohammad Amir and Asieh Heirani Tabasi and Neda Mokhberian and Malihe Hassanzade and Hamid Kalalian Moghaddam and Bahrami, Ahmad Reza and Naghmeh Ahmadiankia},
title = {Analysis of Chemokine Receptor Gene Expression in Esophageal Cancer Cells Compared with Breast Cancer with Insights into Metastasis},
journal = {Iranian Journal of Public Health},
year = {2015},
volume = {44},
number = {10},
month = {October},
issn = {2251-6085},
pages = {1353--1358},
numpages = {5},
keywords = {Esophageal cancer; Breast cancer; Metastasis; Chemokine receptors; Targeted cancer therapy},
}

[Download]

%0 Journal Article
%T Analysis of Chemokine Receptor Gene Expression in Esophageal Cancer Cells Compared with Breast Cancer with Insights into Metastasis
%A Mishan, Mohammad Amir
%A Asieh Heirani Tabasi
%A Neda Mokhberian
%A Malihe Hassanzade
%A Hamid Kalalian Moghaddam
%A Bahrami, Ahmad Reza
%A Naghmeh Ahmadiankia
%J Iranian Journal of Public Health
%@ 2251-6085
%D 2015

[Download]