Journal of Biomedical Materials Research Part A, ( ISI ), Volume (104), No (8), Year (2016-7) , Pages (2020-2028)

Title : ( PGA-incorporated collagen: Toward a biodegradable composite scaffold for bone-tissue engineering )

Authors: Shirin Toosi , H. Naderi-Meshkin , F. Kalalinia , M. Taghi Peivandi , Hossein HosseinKhani , Ahmad Reza Bahrami , Asieh Heirani-Tabasi , Mahdi Mirahmadi , J. Behravan ,

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Nowadays composite scaffolds based on synthetic and natural biomaterials have got attention to increase healing of non-union bone fractures. To this end, different aspects of collagen sponge incorporated with poly(glycolic acid) (PGA) fiber were investigated in this study. Collagen solution (6.33 mg/mL) with PGA fibers (collagen/fiber ratio [w/w]: 4.22, 2.11, 1.06, 0.52) was freeze-dried, followed by dehydrothermal cross-linking to obtain collagen sponge incorporating PGA fibers. Properties of scaffold for cell viability, proliferation, and differentiation of mesenchymal stem cells (MSCs) were evaluated. Scanning electron microscopy showed that collagen sponge exhibited an interconnected pore structure with an average pore size of 190 μm, irrespective of PGA fiber incorporation. The collagen-PGA sponge was superior to the original collagen sponge in terms of the initial attachment, proliferation rate, and osteogenic differentiation of the bone marrow-MSCs (BM-MSC). The shrinkage of sponges during cell culture was significantly suppressed by fiber incorporation. Incorporation of PGA fiber is a simple and promising way to reinforce collagen sponge without impairing biocompatibility. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2020–2028, 2016. © 2016 Wiley Periodicals, Inc.

Keywords

collagen sponge; fiber reinforcement; osteogenic differentiation; poly(glycolic acid); sponge
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@article{paperid:1060275,
author = {Shirin Toosi and H. Naderi-Meshkin and F. Kalalinia and M. Taghi Peivandi and Hossein HosseinKhani and Bahrami, Ahmad Reza and Asieh Heirani-Tabasi and Mahdi Mirahmadi and J. Behravan},
title = {PGA-incorporated collagen: Toward a biodegradable composite scaffold for bone-tissue engineering},
journal = {Journal of Biomedical Materials Research Part A},
year = {2016},
volume = {104},
number = {8},
month = {July},
issn = {1549-3296},
pages = {2020--2028},
numpages = {8},
keywords = {collagen sponge; fiber reinforcement; osteogenic differentiation; poly(glycolic acid); sponge fabrication},
}

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%0 Journal Article
%T PGA-incorporated collagen: Toward a biodegradable composite scaffold for bone-tissue engineering
%A Shirin Toosi
%A H. Naderi-Meshkin
%A F. Kalalinia
%A M. Taghi Peivandi
%A Hossein HosseinKhani
%A Bahrami, Ahmad Reza
%A Asieh Heirani-Tabasi
%A Mahdi Mirahmadi
%A J. Behravan
%J Journal of Biomedical Materials Research Part A
%@ 1549-3296
%D 2016

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