Background: strenuous training‎-induced reactive oxygen species is associated with several ‎chronic diseases‎ by damaging cell proteins and membrane lipids; it seems uric acid as a major ‎intracellular antioxidant could lower membranous lipid peroxidation and muscle damage. The aim ‎of this study was to examine the effect of six weeks of high-intensity interval training with and ‎‎without zinc ‎on serum Creatine Kinase and uric acid in female futsal players.‎ Methods: Thirty-two female futsal players were randomly divided into four groups: placebo, ‎Zinc, ‎HIT ‎and Zinc+HIT. All subjects had to attend futsal-specific training three sessions per ‎week. Zinc and ‎Placebo groups took ‎30 mg ‎day−1 of zinc gluconate or dextrose, respectively; ‎HIT groups accomplished high-intensity interval training contained 6 to 10 repetitions of a 30-‎second ‎running at 100% of VO2peak with a 4-minutes rest between efforts, during six weeks.‎ Results: After six weeks, Creatine Kinase ‎levels augmented insignificantly from 83.98 to 120.19‎ ‎‎(P=0.101) in ‎placebo, from 99.58 to 150.1(P=0.167) in HIT and from 81.07 to 107.90‎ ‎‎(P=0.152) ‎in HIT+Zinc group; while Creatine Kinase ‎levels increased significantly from 66.86 to ‎‎‎124.81(P=0.004) only in Zinc group. Uric acid levels increased in all groups (Placebo (P=1), Zinc ‎‎(P=‎0.317‎), HIT (P=‎0.157‎), ‎Zinc+HIT (P=1)) insignificantly‎.‎ Conclusions: The findings indicated that ‎after six weeks, serum Creatine Kinase and uric acid ‎levels increased insignificantly in all groups; Creatine Kinase ‎levels augmented significantly, only ‎in Zinc group. Zinc as an antioxidant supplement could not decrease the muscle damage, and even ‎increased the serum Creatine Kinase as a marker of muscle damage, significantly.

Keywords