Structural analysis and expression evaluation of the cell surface specific antigens of malignances could be providing new molecular approaches for diagnosis and target therapy of cancers. In this regard, MAGE family with 25 known members and specific expression on the surface of cancerous cells provided a promising perspective for these aims. Bearing in mind, an in-silico expression of these antigens on the cell surface of 20 type of common cancerous and normal tissues were assessment and equilibrated via version 21 of SPSS. On the other hand, topology structures of the antigens were modeled on the surface of the cancerous cells. Moreover, the binding affinity of the selected antigen with corresponding ligands was assessment via molecular docking process. The results of this study led to reveal the different expression of these antigens on the surface of cancers. However, the MAGE-A4 showed the highest expression in the head and neck cancer. Moreover, topology features of this antigen leading to provided several oligopeptides with expression capacity on the surface of cancerous cells with connected to HLA family. In general, the results of this study in addition to detection the expression rate of MAGE family antigens on the surface of cancerous and non-cancerous cells, led to presented the in-silico modeling expression of MAGE-A4 antigen on the surface of cancerous cells for the first time.

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