Title : ( The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazolinduced kindled seizures and anxiety in rats )
Authors: saeede asadi , Ali Roohbakhsh , Ali Shamsizadeh , Masoud Fereidoni , Elham kordi jaz , Ali Moghimi ,
Full TextAbstract
Background: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excita- tory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. The purpose of this study was to evaluate the effect of Orx2 receptor antagonist (TCS OX2 29) on seizures and anxiety of PTZ-kindled rats. Results: Our results revealed that similar to valproate, administration of 7 μg/rat of TCS OX2 29 increased the latency period and decreased the duration time of 3rd and 4th stages of epileptiform seizures. Besides, it signifi- cantly decreased mean of seizure scores. However, TCS OX2 29 did not modulate anxiety induced by repeated PTZ administration. Conclusion: This study showed that blockade of Orx2 receptor reduced seizure-related behaviors without any significant effect on PTZ-induced anxiety.
Keywords
, Anxiety, Kindling, Orexin, OX2 receptor, Seizure
@article{paperid:1062037,
author = {Asadi, Saeede and and and Fereidoni, Masoud and Kordi Jaz, Elham and Moghimi, Ali},
title = {The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazolinduced kindled seizures and anxiety in rats},
journal = {BMC Neuroscience},
year = {2018},
volume = {19},
number = {49},
month = {August},
issn = {1471-2202},
pages = {1--8},
numpages = {7},
keywords = {Anxiety; Kindling; Orexin; OX2 receptor; Seizure},
}
%0 Journal Article
%T The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazolinduced kindled seizures and anxiety in rats
%A Asadi, Saeede
%A
%A
%A Fereidoni, Masoud
%A Kordi Jaz, Elham
%A Moghimi, Ali
%J BMC Neuroscience
%@ 1471-2202
%D 2018
