European Journal of Pharmaceutical and Medical Research, Volume (4), No (2), Year (2017-2) , Pages (126-151)

Title : ( A novel copper-catalyzed c-c bond cleavage of aryl (heteroaryl) alkyl ketones for c-n bond formation )

Authors: Maryam Sadat Hosseini Zare , Mehdi Bakavoli , Hossein Eshghi , Ali Shiri ,

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A direct generation of amide from aryl (heteroaryl) alkyl ketones has been accomplished via copper(II) catalyzed C-C bond cleavage in the presence of diisopropylamine at moderate temperature. The transformation steps for amide formation comprise catalytic generation of α-bromo carbonyl species followed by nucleophilic displacement of bromide with sodium azide in the presence of diisopropylamine. The final step involves the formation of imine by heating in situ followed by hydrolysis to give the related amide.

Keywords

, ketones, cleavage reaction, amide, cupper
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@article{paperid:1062700,
author = {Hosseini Zare, Maryam Sadat and Bakavoli, Mehdi and Eshghi, Hossein and Shiri, Ali},
title = {A novel copper-catalyzed c-c bond cleavage of aryl (heteroaryl) alkyl ketones for c-n bond formation},
journal = {European Journal of Pharmaceutical and Medical Research},
year = {2017},
volume = {4},
number = {2},
month = {February},
issn = {2394-3211},
pages = {126--151},
numpages = {25},
keywords = {ketones; cleavage reaction; amide; cupper catalist.},
}

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%0 Journal Article
%T A novel copper-catalyzed c-c bond cleavage of aryl (heteroaryl) alkyl ketones for c-n bond formation
%A Hosseini Zare, Maryam Sadat
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Shiri, Ali
%J European Journal of Pharmaceutical and Medical Research
%@ 2394-3211
%D 2017

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