Research on Chemical Intermediates, ( ISI ), Volume (43), No (8), Year (2017-2) , Pages (4683-4696)

Title : ( Convenient one-pot access to Novel Densely Functionalized Pyrano[2,3-d][1,3,4]Thiadiazolo[3,2- a]Pyrimidines via Three Component Reaction )

Authors: maryam akhavan nasaj , Abbas Ali Esmaeili , mahdie zangouei , Joel T. Mague ,

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In this work, an efficient isocyanide-based three component method is developed for the synthesis of the novel substituted pyrano[2,3-d][1,3,4]thiadiazolo[3,2- a]pyrimidine system, having both the biologically active pyranopyrimidine and thiadiazolopyrimidine scaffolds, from the readily attainable reaction of 7-hydroxy-2-phenyl-5H- [1,3,4]thiadiazolo[3,2-a]pyrimidine-5-one, isocyanides, and dialkylacetylenedicarboxylates. This procedure has the chief advantages of fairly high reaction yields, mild reaction conditions, high atom-economy, and catalyst-free reaction.

Keywords

, Multicomponent reaction, Dialkylacetylenedicarboxylates, Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine, Alkyl isocyanide,
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@article{paperid:1063524,
author = {Akhavan Nasaj, Maryam and Esmaeili, Abbas Ali and Zangouei, Mahdie and Joel T. Mague},
title = {Convenient one-pot access to Novel Densely Functionalized Pyrano[2,3-d][1,3,4]Thiadiazolo[3,2- a]Pyrimidines via Three Component Reaction},
journal = {Research on Chemical Intermediates},
year = {2017},
volume = {43},
number = {8},
month = {February},
issn = {0922-6168},
pages = {4683--4696},
numpages = {13},
keywords = {Multicomponent reaction; Dialkylacetylenedicarboxylates; Pyrano[23- d][134]thiadiazolo[32-a]pyrimidine; Alkyl isocyanide; 7-Hydroxy-2-phenyl-5H- [134]thiadiazolo[32-a]pyrimidine-5-one},
}

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%0 Journal Article
%T Convenient one-pot access to Novel Densely Functionalized Pyrano[2,3-d][1,3,4]Thiadiazolo[3,2- a]Pyrimidines via Three Component Reaction
%A Akhavan Nasaj, Maryam
%A Esmaeili, Abbas Ali
%A Zangouei, Mahdie
%A Joel T. Mague
%J Research on Chemical Intermediates
%@ 0922-6168
%D 2017

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