Research on Chemical Intermediates, ( ISI ), Volume (43), No (8), Year (2017-2) , Pages (4683-4696)
Title : ( Convenient one-pot access to Novel Densely Functionalized Pyrano[2,3-d][1,3,4]Thiadiazolo[3,2- a]Pyrimidines via Three Component Reaction )
Authors: maryam akhavan nasaj , Abbas Ali Esmaeili , mahdie zangouei , Joel T. Mague ,
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Abstract
In this work, an efficient isocyanide-based three component method is developed for the synthesis of the novel substituted pyrano[2,3-d][1,3,4]thiadiazolo[3,2- a]pyrimidine system, having both the biologically active pyranopyrimidine and thiadiazolopyrimidine scaffolds, from the readily attainable reaction of 7-hydroxy-2-phenyl-5H- [1,3,4]thiadiazolo[3,2-a]pyrimidine-5-one, isocyanides, and dialkylacetylenedicarboxylates. This procedure has the chief advantages of fairly high reaction yields, mild reaction conditions, high atom-economy, and catalyst-free reaction.
