Russian Journal of Bioorganic Chemistry, Volume (43), No (5), Year (2017-9) , Pages (576-582)

Title : ( Benzothiazole Thiourea Derivatives as Anticancer Agents: Design, Synthesis, and Biological Screening )

Authors: fatemeh eshkil , Hossein Eshghi , Amir SHokooh Saljooghi , Mehdi Bakavoli , Mohammad Rahimizadeh ,

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In a systematic effort to identify a potent anticancer agent, we synthesized benzothiazole thiourea derivatives and examined their cytotoxic activity against five different human and animal cancer cell lines. Benzothiazolylthiocarbamides have been prepared in excellent yields by reaction of substituted 2-amino benzothiazoles with carbon disulfide and dimethyl sulfate followed by their ammonolysis. Cytotoxicity of the four compounds were screened for antitumor activity against human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line (K-562), and mouse neuroblastoma cell line (Neuro-2a) using cisplatin as a reference by MTT assay. Our results presented herein provide experimental evidence that benzothiazolylthiocarbamides induce apoptosis in cancer cell lines. According to flow cytometry results, treatment of HT-29 cells with 1-(6-ethoxy-1,3-benzothiazol-2-yl)thiourea produced a large population of apoptotic cell (79.45%), which was 1.2-fold higher than that produced by cisplatin (65.28%) at the same concentration.

Keywords

, anticancer activity, benzothiazolylthiocarbamides, MTT assay, flow
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@article{paperid:1063714,
author = {Eshkil, Fatemeh and Eshghi, Hossein and SHokooh Saljooghi, Amir and Bakavoli, Mehdi and Rahimizadeh, Mohammad},
title = {Benzothiazole Thiourea Derivatives as Anticancer Agents: Design, Synthesis, and Biological Screening},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
number = {5},
month = {September},
issn = {1068-1620},
pages = {576--582},
numpages = {6},
keywords = {anticancer activity; benzothiazolylthiocarbamides; MTT assay; flow cytometry},
}

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%0 Journal Article
%T Benzothiazole Thiourea Derivatives as Anticancer Agents: Design, Synthesis, and Biological Screening
%A Eshkil, Fatemeh
%A Eshghi, Hossein
%A SHokooh Saljooghi, Amir
%A Bakavoli, Mehdi
%A Rahimizadeh, Mohammad
%J Russian Journal of Bioorganic Chemistry
%@ 1068-1620
%D 2017

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