In the field ofmedicinal inorganic chemistry, an increasing attention has been paid to the design of metal-based compounds as therapeutic agents. The anticancer potential of these compounds was fully examined after the discovery ofcisplatin, which still remains one of the most effective chemotherapeutic agents. However, the clinical use of cisplatin is severely limited by side effects,systemic toxicityand drug resistance. Many studies have been done on copper complexes as anticancer agents with this assumption that endogenous metals may have less toxicity.In this study,the cytotoxiceffects of complex pyridine dicarboxylate cu (II) was investigated on CT26, C26, 4T1 andTubomouse cell lines. For this purpose, these cells were treated with different concentrations of this complex for 24, 48 and 72 hours. Then, cell death was assessed by MTT assay and IC50values for CT26, C26, 4T1, Tubo cell lines wereroughly calculated as39, 36, 24and 35 μg/ ml after 48 hours of treatment, respectively.The results of this study showed the same effects on the cell toxicity of complex pyridinedicarboxylato Cu (II)on the target cells. So, it is possible to achieve a compound with higher cell toxicity effect by altering the chemical structure of this complex.

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