Herbal Medicineshave been widely considered in recent decades due to the publication of numerous studies and researches on medicinal herbs and their active compounds,which suggests having great properties and different treatment features.Sesquiterpene Lactones are one of the largest active compoundgroups found in many plants, especially the Asteraceae family,and have shown therapeutic properties in various fields, including anti-cancer properties.Cynaropicrinis a member of this family which has been studied to identify its properties, especially anti-cancer properties, on various cancer cell lines. Considering the prevalence of esophageal cancer and the presence of Iran on the esophageal cancer belt, as well as the lack of a study about the effects of cynaropicrin on this cancer, this study investigated the anticancer effects of cynaropicrin on squamous cell carcinoma (KYSE30) in comparison with healthy human fibroblasts (HDF) cells.The results showed the anticancer effects of cynaropicrin onesophagus cancer cells, compared to HDF cells.With respect to the previous studies on cynaropicrin and results of the present study, it seems that thiscompound can be considered as an anticancer drug in the pre-clinical studies level.

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