Objectives: Transcranial direct current stimulation is a novel technological method that has been used in the scope of pain related diseases like migraine-as a prevalent and high burden disease extensively. The aim of the present study was to evaluate the effectiveness of cathodal transcranial direct current stimulation (c-tdcs) over the right primary motor (M 1 ) and sensory (S 1 ) areas of the cortex on decreasing the intensity, duration, and frequency of pain in migraineurs. Methods: This study was based on a randomized, doubleblind, and sham-controlled design, and it tested 15 seasons (every week three seasons; over 5 consecutive weeks) of c-tdcs (20 min/1000a) on forty-five migraineurs (diagnosed according to the IHCD-II) into two experimental (nm ¼ 15;ns¼ 15) and a control group (nc ¼ 15). Image: Results: The results of a series of one-way ANOVA, c-tdcs showed significant (p < 0.05) reductions in all hypothesized aspects of pain in both experimental groups compared to the control one. Conclusion: Therefore, it seems that c-tdcs can be used as a technological method in the treatment of migraine both therapeutically and prophylactically.

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