Adiponectin is one of the plasma protein derived from adipose tissue which has a positive effect on metabolism of fat and lipid, resulting from its own receptors. Increase in body mass index (BMI) has a direct relationship with life length. Obesity has effects on secretion of some hormons related to adipokines. Adiponectin is an adipokine having an opposite relationship with insulin resistance and breast cancer. It is also the connection between breast cancer incidence and obesity. Adiponectin level decreases in women affected by breast cancer and knowing this fact can help treat and prevent the cancer by giving adiponectin supplements. The present study compared the adiponectin levels in women affected by breast cancer and healthy females as control group. Method: in this study, 80 women with breast cancer and 80 healthy females as controls were selected and adiponectin level was compared between them. Result: the group with breast cancer, having a higher BMI mean (28.77 ± 6.05), showed a lower adiponectin level in comparison to control group .(p= 0.0001). Conclusion: Considering the fact that the risk is higher in women with bigger BMI value, informing women in this regard could have a great effect on preventing this wide-spread disease. Taking adiponectin supplements as pills or injection could be a preventing step for breast cancer, which needs to be considered as targets for future studies

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