The best place for detection, treatment, and prevention of different diseases with more precision and less noise is their own microenvironments. The microenvironment approach leads to a dynamic local-global vision using fewer intermediate processes and results in more decision knowledge. The synergy of nano technology and artificial intelligence promises to shed light on this approach, and brings out the bright dreams into the hands of labs. In this paper we propose an in silico nano delivery system for cellular exchanging. Here, a cell-free therapy using engineered exosomes which are non-toxic, non-immunogenic, and capable for doing targeted delivery in challenging situation such as Blood Brain Barrier (BBB) are introduced as nano carriers, and their functions are completely reviewed, then an in silico nano delivery system for cellular exchanging is presented using proper disease markers.

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