Journal of Heterocyclic Chemistry, ( ISI ), Volume (55), No (9), Year (2018-7) , Pages (2055-2060)

Title : ( An Alternative Regioselective Approach for the Synthesis of Highly Functionalized Derivatives of Pyrazolo[5,1-b]purine Scaffold )

Authors: Seddigheh Sheikhi-Mohammareh , Ali Shiri ,

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Abstract

A straightforward approach for the regioselective synthesis of highly functionalized pyrazolo[5,1-b]purine from the annulation of 6-bromo-3-cyano-2-(ethylthio)-5-methyl-7-oxo-6,7-dihydropyrazolo[1,5-a]pyrimidine with thiourea as a bisnucleophilic reagent under reflux condition in CH3CN in the presence of Et3N has been developed. The N-alkylation of the synthesis compound was also accomplished. The true regioisomer was determined by 2D-NOESY NMR spectroscopy, as well.

Keywords

, Regioselective Approach, Highly Functionalized, Pyrazolo[5, 1-b]purine Scaffold
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@article{paperid:1069481,
author = {Sheikhi-Mohammareh, Seddigheh and Shiri, Ali},
title = {An Alternative Regioselective Approach for the Synthesis of Highly Functionalized Derivatives of Pyrazolo[5,1-b]purine Scaffold},
journal = {Journal of Heterocyclic Chemistry},
year = {2018},
volume = {55},
number = {9},
month = {July},
issn = {0022-152X},
pages = {2055--2060},
numpages = {5},
keywords = {Regioselective Approach; Highly Functionalized; Pyrazolo[5;1-b]purine Scaffold},
}

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%0 Journal Article
%T An Alternative Regioselective Approach for the Synthesis of Highly Functionalized Derivatives of Pyrazolo[5,1-b]purine Scaffold
%A Sheikhi-Mohammareh, Seddigheh
%A Shiri, Ali
%J Journal of Heterocyclic Chemistry
%@ 0022-152X
%D 2018

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